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By A. Bertossi

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His research interests include security informatics, infectious disease informatics, spatiotemporal data analysis, software agents and their applications, computational support for auctions and negotiations, and recommender systems. He has coedited two books and published about 60 peer-reviewed articles in Management Information Systems and Computer Science journals, edited books, and conference proceedings. He also serves on the editorial boards of two Information Technology-related journals. edu/-zengl) PREFACE The field of medical informatics has grown rapidly over the past decade due to the advances in biomedical computing, the abundance of biomedical and genomic data, the ubiquity of the Internet, and the general acceptance of computing in various aspects of medical, biological, and health care research and practice.

Despite its early success, it was never used in actual clinical settings. Other medical diagnostic systems were also seldom used clinically. The reasons were two-fold. First, people were skeptical about computer technologies and system performances. Computers were not popular at that time, and many physicians did not believe that computers could perform better than humans. Second, computers were big, expensive machines in the 1970s. It was not feasible to support complex programs like MYCIN on an affordable computer to provide fast responses (Shortliffe, 1987).

Mukhopadhyay is a holder of degrees from Jadavpur University, India and the Indian Institute of Science, India as well as a Master of Science and Doctorate in Electrical Engineering from Yale University. His research interests include Intelligent Systems, Neural Networks, Multi-Agent Systems, Intelligent Information Filtering, and Bioinformatics. He is a National Science Foundation CAREER Award recipient in 1996. edu) L4 a 9 xxxii Mathew Palakal, PhD, is a Professor and Chair of the Department of Computer and Information Science and Director of Informatics Research Institute at Indiana University Purdue University Indianapolis.

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