By John R. Baker, Ralph Muller, David Rollinson
Advances in Parasitology is a chain of in-depth reports on present issues of curiosity in modern parasitology. It contains clinical reports on parasites of significant impact, corresponding to trypanosomiasis and scabies, and extra conventional components, equivalent to zoology, taxonomy, and existence heritage, which form present pondering and functions.
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Additional resources for Advances in Parasitology, Vol. 48
Equatoriensis sequences (GenBank accession nos. AF133836 and AF133837, respectively); analysis was performed using the program DNAML (which does not assume a molecular clock) in PHYLIP (Felsenstein, 1993). Scale bar denotes expected numbers of substitutions averaged over all sites analysed (see DNAML documentation). The same topology was also found by parsimony analysis (DNAPARS). s. clade, support for which was 28 points higher by parsimony (shown in bold type). W. = Old World. R. A. J. SCHOFIELD AND W.
P. , 1999b). A major DNA-based study is required to resolve the phylogeny of the phlebotomine sandflies with confidence and to provide an essential test for the hypothesis of a New World origin of Leishmania. 5. Other DNA Sequences Conclusions relating to L. 3, p. 4, p. 38) are confirmed by the work of Cupolillo et al. (1998), who used short (83 bp) sequences from the conserved region of kinetoplast DNA minicircles and isoenzyme data to confirm the close relationship between L. equatoriensis/L, colombiensis and Endotrypanum species (Figure 6).
85% substitutions per 100 million years derived from ribosomal RNA analysis of metazoans (Escalante and Ayala, 1995), and of 340 mybp proposed by Fernandes et al. (1993) for the trypanosome and Leishmania lineages, are questionable. Nevertheless, within a given taxonomic group and well defined categories of genetic marker, the concept of a molecular 'clock' may be usefully employed for dating species divergence. 2. Evolutiona O, Rates Recent studies of trypanosome phylogenies based on ssu rRNA have identified considerable differences in genetic diversity within clades in the genus Trypanosoma, focusing in particular on the apparently high rate of sequence evolution within T.