By Leo Sachs (auth.), Prof. Dr. W. Hiddemann, Priv.-Doz. Dr. W. Plunkett, Prof. Dr. T. Büchner, Prof. Dr. J. Ritter, B. Wörmann M.D., Ph.D., M. J. Keating M.D., B.S., Prof. Dr. U. Creutzig (eds.)
This quantity, the 5th in a sequence on acute leukemias, focuses quite on fresh simple examine effects and novel healing ways to the disorder. features of leukemia phone biology, together with differentiation, the mechanisms of drug resistance, the pharmacology of cytostatic brokers and the result of scientific trials in relapsed and refractory sickness are coated by means of extraordinary overseas specialists within the respective fields. destiny advancements together with new brokers and new treatments resembling unrelated bone marrow transplantation, immunotargeting and gene remedy whole a cutting-edge summery of present wisdom in experimental leukemia therapy.
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Extra info for Acute Leukemias V: Experimental Approaches and Management of Refractory Disease
USA 68: 1542-1546. 14. A. 1975. Growth of B lymphocyte colonies in vitro. J. Exp. Med. 142: 1534-1549. 15. , Sachs 1. 1976. Regulation of the induction of colonies in vitro by normal human lymphocytes. Proc. Nat!. Acad. Sei. USA 73: 4546-4550. 16. , Sordat B. 1975. Growth of mouse megakaryocyte colonies in vitro. Proc. Nat!. Acad. Sci. USA 72: 1744-1748. 17. , Sachs 1. 1989. Regulation of meagakaryocyte development by interleukin-6. Blood 74: 1545-1551. 18. Sachs 1. 1970. In vitro control of growth and development of hematopoietic cell clones.
Int. J. Cancer 28: 375-386 43. , Sachs L. 1984. Control of in vivo differentiation of myeloid leukemic cells. IV. Inhibition of leukemia development by myeloid differentiationindueing protein. Int. J. Cancer 33: 147-154. 44. , Sachs, L. 1982. Participation of myeloid leukaemic cells injected into embryos in haematopoietic differentiation in adult mice. Nature, 299: 63-65. 45. , Sachs, L. 1984. Developmental potential of myeloid leukemia cells injected into mid-gestation embryos. Develop. Bio!. 101: 221-224.
J. Nat!. Cancer Inst. 31: 1-40. 2. Sachs, L. 1978. Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia. Nature, 274: 535-539. 3. Sachs, L. 1986. Growth, differentiation and the reversal of malignancy. Seientific American, 254: 40-47· 4. Sachs, L. 1987. The molecular control of blood cell development. Seience, 238: 1374-1379. 5. Sachs, L. 1990. The control of growt11 and differentiation in normal and leukemic blood cells. The 1989 Alfred P. Sloan Prize of ilie General Motors Cancer Research Foundation.