By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This ebook is the 6th quantity within the sequence Acute publicity instruction degrees for Selected Airborne Chemicals, and comprises AEGLs for chemical compounds similar to ammonia, nickel carbonyl and phosphine, between others.
At the request of the dep. of protection, the nationwide examine Council has reviewed the suitable clinical literature compiled by means of a professional panel and tested Acute publicity instruction degrees (AEGLs) for 12 new chemical compounds. AEGLs characterize publicity degrees less than which antagonistic healthiness results aren't more likely to ensue and are necessary in responding to emergencies resembling unintended or intentional chemical releases locally, the place of work, transportation, the army, and for the remediation of infected sites.
Three AEGLs are authorized for every chemical, representing publicity degrees that bring about: 1) awesome yet reversible soreness; 2) long-lasting overall healthiness results; and three) life-threatening wellbeing and fitness impacts.
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Extra info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6
1960; Guzman et al. 1961). Exposure to vaporized liquid allylamine was in 200-L stainless steel chambers. Air allylamine concentrations were sampled periodically, and allylamine was measured using a method designed to measure ammonia (Goldman and Jacobs 1953). No effects were seen in rats exposed to 5 ppm, with the exception of one rat that was considered an outlier (it had heart lesions, extensive abdominal tumors, hepatic abscess, and lung atelectasis). Rats exposed to 10 ppm and higher had lowered weight gain, which was correlated at 20 ppm with depletion of body fat.
14 ppm) found to be intolerable by humans (Hine et al. 1960). 7-ppm odor threshold was not reported, which may explain its discrepancy with the Hine et al. , a higher concentration may be needed for detection by sniffing for a few seconds than by inhalation for 5 min). 2. 5, 5, 10, or 14 ppm (10-14 per concentration; sex and age not specified; Hine et al. 1960). It was not specified whether the same persons were exposed to more than one concentration. To compensate for the loss of allylamine upon the entrance of subjects into the 16,680-L chamber, the initial concentration of allylamine in the chamber Copyright © National Academy of Sciences.
Copyright © National Academy of Sciences. All rights reserved. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 17 Allylamine TABLE 1-1 Summary of AEGL Values for Allylamine End Point (Reference) Mild human irritation or discomfort (Hine et al. 8 mg/m3) Human eye and respiratory irritation and NOAEL for severe irritation (≤1 h; Hine et al. 1960); NOAEL for cardiovascular lesions in rats (≥4 h; Guzman et al. 4 mg/m3) Lethality NOEL in rats (Hine et al. 5 ppm. 5ppm based on the human study of Hine et al.