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29th Annual General Meeting of the European Brain and by Nicole von Steinbüchel, Alexander Steffen, Marc Wittmann

By Nicole von Steinbüchel, Alexander Steffen, Marc Wittmann

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Our investigation showed that, for the parameter fundamental frequency, there were individual differences in reaction to stress, and that there were sex differences, too. S29 ES/7 FEAR AND AGGRESSIVE RESPONSES IN NUCLEUS BASALIS MAGNOCELLULARIS-LESIONED RATS TREATED WITH VERAPAMIL. M. Popovic1 , K. Jovanova-Nesic 1, N. Popovic1 , D. Bokonjic2 , S. Dobric , and N. Ugresic 3 • 1 Immunology Research Center "Branislav Jankovic", Vojvode Stepe 458; 2 Medical Department, Military Technical Institute, Kataniceva 15 and 3 Department of Pharmacology, Faculty of Pharmacy, Vojvode Stepe 450, 11000 Belgrade, FR Yugoslavia It was found that excessive calcium influx represents the final common pathway of neuronal death.

Most important for its activation is the dimerisation of the enzyme and contact to Ca-calmodulin in a Ca++ dependent way. Increase of intracellular Ca++ by the activation of NMDA-receptors is followed by NOS-activation. NO triggers futher second messenger cacades via activation of the soluble guanylate cyclase. The conditions in the spinal cord are unique that only unmyelated small calibre afferents - C-fibres - release neuropeptides like SP which is known to deblockade NMDA-receptors. Myelinated A-fibres release probably glutamat.

The conditions in the spinal cord are unique that only unmyelated small calibre afferents - C-fibres - release neuropeptides like SP which is known to deblockade NMDA-receptors. Myelinated A-fibres release probably glutamat. Our model allows to stimulate all fibres including C-fibres and myelinated fibres separately. The sciatic nerve was stimulated while the compound action potential was monitored from the suralis nerve to control selective stimulation. NOSimmunoreactivity and NOSmRNA expression (only evaluated in L3 after 2h) of the lumbar segments L3 as a marginal target of sciatic afferents and the segement L5 as the main target were evaluated.

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